Want to Prevent Cancer?

Want to Prevent Cancer?

The great grape.

Preventing or fighting cancer begins at the cellular level. Exciting new research shows that OPCs in grape seed extract exert anticancer properties in colorectal cancer cells. But only one type of grape seed extract has been proven successful.

This article from Terry Talks Nutrition provides the newest information.

TERRY’S BOTTOM LINE:

“Few things get me as excited as proven research on the power of plants and botanicals to improve health, and this study on a unique grape seed extract was just too amazing to keep to myself. Read on to learn how researchers are finding more on how French grape seed extract fights cancer. Who knows—this information may save your life, or the life of someone you love. Read it and pass it on!”

—   Terry Lemerond

GRAPE SEED OPCs AND TUMOR FORMATION

Mechanistic insights into anticancer properties of oligomeric proanthocyanidins from grape seeds in colorectal cancer.
Ravindranathan P, Pasham D, Balaji U, Cardenas J, Gu J, Toden S, Goel A. Carcinogenesis. 2018 May 28;39(6):767-777.

Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer cell lines, we for the first time illuminate the genome-wide effects of OPCs from grape seeds (VX1®) in colorectal cancer.

Our data revealed that OPCs affect several key cancer associated genes. In particular, genes involved in cell cycle and DNA replication were most significantly and consistently altered by OPCs across multiple cell lines. Intriguingly, our in vivo experiments showed that OPCs were significantly more potent at decreasing xenograft tumor growth compared with the unfractionated grape seed extract (GSE) that includes the larger polymers of proanthocyanidins.

These findings were further confirmed in colorectal cancer patient-derived organoids, wherein OPCs more potently inhibited the formation of organoids compared with GSE. Furthermore, we validated alteration of cell cycle and DNA replication-associated genes in cancer cell lines, mice xenografts, as well as patient-derived organoids. Overall, this study provides an unbiased and comprehensive look at the mechanisms by which OPCs exert anticancer properties in colorectal cancer.

 

What It Means to You:

OPC’s from French Grape Seed Extract show great promise in the fight against cancer. Additionally, this study demonstrates that a specific grape seed OPC extract with small, absorbable compounds outperforms standard grape seed extract that contains large tannins that cannot be absorbed. This is why researchers will be focusing on extracts proven to contain only small, absorbable OPC’s.

Colorectal cancer has the second highest mortality rate in the United States, so finding an effective way to fight it is critical. While lifestyle and diet can prevent or modify the risk, there is an urgent need for effective therapies that don’t come with terrible side effects. Grape seed extract, especially one rich in tannin-free, fully absorbable OPCs can help prevent colon cancers from forming and help stop them from recurring. The French grape seed extract used in the most successful studies outperforms standard grape seed extract, so it is important to choose wisely.

Remember to sign up for your free Healthy Living / Personal Development book a month

Also check out our book site for help with Healthy Living Solutions.


Also check out our site where we have great recipes.


Have a Healthy Day!,

.

Rod Stone
Author,
Publisher and Founder of r Healthy Living Solutions, LLC,  Supplier of Healthy Living information and products to improve
your life.


Important
This site makes use of cookies which may contain tracking information about visitors. By continuing to browse this site you agree to our use of cookies.