The Spice That May Be 10,000x More Effective Than Chemo

The Spice That May Be 10,000x More Effective Than Chemo

Ginger: super spice

A new scientifically rigorous peer-reviewed cancer study reveals a highly significant finding.

If cancer treatment is to achieve a lasting cure, the cancer stem cells within a tumor must be destroyed. However, cancer stem cells are resistant to chemotherapy. And in some circumstances, both chemotherapy and radiation can actually increase the number of cancer stem cells.

That’s one of the reasons that fighting cancer has been so difficult, and why chemotherapy and radiation have not had better results. But now, researchers have identified a natural substance that could be up to 10,000 times more powerful at fighting cancer stem cells than chemo.

Find out all the details in this article from the Food Revolution Network.

Ginger and Cancer: How A Compound in Ginger Could Kill
The Root Cause of Cancer

A 2015 study published in PLoS reveals a
pungent component within ginger known as 6-shogaol is
superior to conventional chemotherapy in targeting the root cause of breast
cancer malignancy: namely, the breast cancer stem cells.

As we have discussed in greater detail in a previous article
titled, “Cancer Stem Cells: The Key To Curing Cancer,” cancer
stem cells are at the root of a wide range of cancers
, not just breast
cancer, and are sometimes referred to as “mother cells” because they are
responsible for producing all the different “daughter” cell types that make up
the tumor colony.

While cancer stem cells only constitute between .2 and 1% of
the cells within any given tumor, they:

  • Have the seeming “immortal” ability to self-renew

  • Are capable of continuous differentiation

  • Are resistant to conventional chemotherapeutic
    agents, and

  • Are tumorigenic, i.e. are capable of
    “splitting off” to create new tumor colonies

Clearly, the cancer stem cells within a tumor must be
destroyed if cancer treatment is to effect a lasting cure.

More About the Ginger and Cancer Study

The study titled, “6-Shogaol Inhibits Breast Cancer Cells and Stem
Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of
Autophagic Cell Death,” identified powerful anti-cancer stem cell activity
in 6-shogaol, a pungent constituent of ginger produced when the root is
either dried or cooked

The study also found that the cancer-destroying
effects occurred at concentrations that were non-toxic to non-cancerous cells
a crucial difference from conventional cancer treatments that do not exhibit this kind of selective cytotoxicity and
therefore can do great harm to the patient.

The authors of the study further affirm these points:

“Cancer stem cells pose serious obstacle to cancer
therapy as they can be responsible for poor prognosis and tumor relapse.

To add into the misery, very few chemotherapeutic
compounds show promise to kill these cells. Several researchers have shown that
cancer stem cells are resistant
to paclitaxel, doxorubicin, 5-fluorouracil, and platinum drugs
[8, 16]. CSCs are thus an almost unreachable population
in tumors for chemotherapy.

Therefore any compound, that shows promise towards cancer
stem cells, is a highly desirable step towards cancer treatment and should be
followed up for further development.”

The researchers identified a variety of ways by which
6-shagoal targets breast cancer:

  • It reduces the expression of CD44/CD24 cancer stem
    cell surface markers in breast cancer spheroids (3-dimensional cultures of
    cells modeling stem-cell-like cancer)
  • It significantly affects the cell cycle, resulting in
    increased cancer cell death
  • It induces programmed cell death primarily through
    the induction of autophagy, with apoptosis a secondary inducer
  • It inhibits breast cancer spheroid formation by
    altering Notch signaling pathway through γ-secretase inhibition
  • It exhibits cytotoxicity (cell killing
    properties) against monolayer (1-dimensional cancer model) and
    spheroid cells (3-dimensional cancer model)

It was in evaluating the last mode of 6-shagoal’s
chemotherapeutic activity and comparing it to the activity of the
conventional chemotherapeutic agent taxol that the researchers discovered
an astounding difference.

Ginger Heals Without Harm

Whereas taxol exhibited clear cytotoxicity in the
one-dimensional (flat) monolayer experimental model, it had virtually no effect
on the spheroid model, which is a more “real world” model reflecting the
3-dimensionality of tumors and their stem cell subpopulations. Amazingly, this
held true even when the concentration of taxol was increased by four orders of

“In contrast [to 6-shagoal], taxol, even though was
highly active in monolayer cells, did not show activity against the
spheroids even at 10000 fold higher concentration compared to 6-shogoal.”

This is a highly significant finding, as it affirms a
common theme in cancer research that acknowledges the primarily role of cancer
stem cells: namely, while conventional techniques like surgery, radiation, and
chemotherapy are effective at reducing a tumor’s size, sometimes to the point
where it is “debulked,” burned,” or “poisoned” out of the body even below the
threshold of re-detection, the appearance of “winning the battle” often comes
at a steep price, as ultimately the cancer stem cell population regrows the
tumors, now with increased vengeance and metastastic invasiveness, resulting in
the cancer “winning the war.”

The monolayer model, which does not account for the complex
immunity of actual cancer stem-cell based tumors against chemoagents like
taxol, represents the old preclinical model of testing cancer treatments. The
spheroid model, on the other hand, clearly shows that even 10,000 times higher
concentrations of taxol are not capable of beating this ginger component
at selectively targeting the root cause of the tumor malignancy.

In their concluding remarks, the authors point out a hugely
important distinction between natural anti-cancer agents and conventional ones that
have only been introduced in the past half-century or so, namely,

“Dietary compounds are welcome options for human diseases
due to their time-tested acceptability by human bodies.”

Unlike modern synthetically produced and patented chemicals,
ginger, curcumingreen tea, and hundreds of other compounds naturally found
in the human diet, have been “time-tested” as acceptable to the human body
the largest and longest running “clinical trials” known: the tens of thousands
of years of direct human experience, spanning thousands of different cultures
from around the world, that constitute human prehistory.

These experientially-based “trials” are validated not
by RCTs, or a peer-reviewed publication process, but by the fact that we all
made it through this incalculably vast span of time to be alive here today.

Consider also that if our ancestors made the wrong dietary
choice by simply mistaking an edible berry for a poisonous one, the
consequences could be deadly.

This places even greater emphasis on how the “time testing”
of dietary compounds was not an academic but a life-death affair, and by
implication, how the information contained within various cultural traditions
as “recipes” passed down from generation to generation are “epigenetic
inheritance systems” no less important to our health and optimal gene
expression as the DNA in our own bodies.

Ultimately, this new study adds to a growing body of research
indicating that cancer-stem-cell-targeting approaches using natural
substances present in the human diet for thousands of years are far superior
chemotherapy and radiation,
 both of which actually increase the relative populations of cancer stem cells versus
non-tumorigenic ones.

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